Amino acids and diabetes: implications for endocrine, metabolic and immune function.

نویسندگان

  • Philip Newsholme
  • Fernando Abdulkader
  • Eduardo Rebelato
  • Talita Romanatto
  • Carlos Hermano J Pinheiro
  • Kaio Fernando Vitzel
  • Erica Portioli Silva
  • Roberto B Bazotte
  • Joaquim Procopio
  • Rui Curi
  • Renata Gorjao
  • Tania Cristina Pithon-Curi
چکیده

Aberrant alterations in glucose and lipid concentrations and their pathways of metabolism are a hallmark of diabetes. However, much less is known about alterations in concentrations of amino acids and their pathways of metabolism in diabetes. In this review we have attempted to highlight, integrate and discuss common alterations in amino acid metabolism in a wide variety of cells and tissues and relate these changes to alterations in endocrine, physiologic and immune function in diabetes.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

EVALUATION OF METABOLIC PROFILE OF PLASMA AMINO ACIDS IN DIABETIC PATIENTS WITH CARDIOVASCULAR DISEASES

Background: Diabetes mellitus is one of the most common endocrine diseases. Cardiovascular disease (CVD) is one of the leading causes of death in patients with type 2 diabetes. The aim of this study was to investigate the metabolic profile of plasma amino acids in diabetic patients with cardiovascular disease. Methods: The present study is a descriptive-analytical cross-sectional study on 140 ...

متن کامل

A Review on Recent Findings on Amino Acids Requirements in Poult-Studies

Amino acids (AA) are important in poultry nutrition not only for protein deposition, but also for other metabolic functions; such as improving immune and gut functions. Although, some table values are available on amino acids requirement, AA requirements may vary due to changes in dietary composition and breeding selection. Thus amino acids requirements have remained an ongoing research topic. ...

متن کامل

Diabetes Mellitus and Impairment of Male Reproductive Function: Role of Hypothalamus Pituitary Testicular Axis and Reactive Oxygen Species

Abstract Diabetes mellitus (DM) is one of the greatest public health threats in modern societies. Although during a few years it was suggested that DM had no significant effect in male reproductive function, this view has been challenged in recent years. From a clinical perspective, the evaluation of semen parameters, as well as spermatozoa deoxyribonucleic acid (DNA) integrity, are often st...

متن کامل

Reciprocal Association between Thyroid Function and Metabolic Syndrome: A Review Article

Introduction: Thyroid dysfunction can impair fat and glucose metabolism, blood pressure, and body weight. On the other hand, metabolic syndrome (MetS) can be associated with an increased risk of hypothyroidism. Due to the high prevalence of both disorders and the possibility of synergistic metabolic detrimental consequences in combination, this review study aimed to investigate the reciprocal a...

متن کامل

Endogenous metabolites as ligands for G protein-coupled receptors modulating risk factors for metabolic and cardiovascular disease.

During the last decade, several G protein-coupled receptors activated by endogenous metabolites have been described. These receptors respond to fatty acids, mono- and disaccharides, amino acids, or various intermediates and products of metabolism, including ketone bodies, lactate, succinate, or bile acids. Receptors of endogenous metabolites are expressed in taste cells, the gastrointestinal tr...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Frontiers in bioscience

دوره 16  شماره 

صفحات  -

تاریخ انتشار 2011